Age-Dependent Susceptibility to Manganese-Induced Neurological Dysfunction
نویسندگان
چکیده
منابع مشابه
Age-dependent susceptibility to manganese-induced neurological dysfunction.
Chronic exposure to manganese (Mn) produces a spectrum of cognitive and behavioral deficits associated with a neurodegenerative disorder resembling Parkinson's disease. The effects of high-dose exposure to Mn in occupational cohorts and in adult rodent models of the disease are well described but much less is known about the behavioral and neurochemical effects of Mn in the developing brain. We...
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Background Age has been recognized as an important contributor into susceptibility to alcohol-driven pathology. Purpose We aimed at determining whether alcohol-induced constriction of cerebral arteries was age-dependent. Study design We used rat middle cerebral artery (MCA) in vitro diameter monitoring, patch-clamping and fluorescence labeling of myocytes to study an age-dependent increase ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2009
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfp220